In the event that you need to disable PHP‘s APC, Advanced PHP Cache, module for a single domain, add the following to the Apache configuration:

<Directory /path/to/docroot>
php_admin_flag apc.enabled “0″
</Directory>

If you want to do this on the fly for developers so they can actually see their changes before the cache updates, simply throw it into a .htaccess file in the DocumentRoot.

/cs